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By Ivan Mura (auth.), Luis F. Castillo, Marco Cristancho, Gustavo Isaza, Andrés Pinzón, Juan Manuel Corchado Rodríguez (eds.)

ISBN-10: 3319015672

ISBN-13: 9783319015675

ISBN-10: 3319015680

ISBN-13: 9783319015682

This quantity compiles authorised contributions for the 2d variation of the Colombian Computational Biology and Bioinformatics Congress CCBCOL, after a rigorous evaluation method within which fifty four papers have been authorized for ebook from 119 submitted contributions. Bioinformatics and Computational Biology are parts of data that experience emerged because of advances that experience taken position within the organic Sciences and its integration with info Sciences. the growth of initiatives concerning the learn of genomes has led the best way within the creation of giant quantities of series facts which should be prepared, analyzed and saved to appreciate phenomena linked to residing organisms relating to their evolution, habit in several ecosystems, and the advance of purposes that may be derived from this analysis.

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Taken together, these results suggest a fundamental cross talk between these tyrosine kinase coupled receptors, in signal transduction [9]. However, at the present moment there is no information regarding the possible interaction between the PDGFBB and the EGFR at the molecular level. The structural analysis of complexes between EGFR in complex with PDGFB is unknown, due to the lack of suitable crystal structure and difficulties of protein multimerization in solution [1,9,18]. In the present study, molecular modeling, protein–protein docking simulations and docking validation with bioinformatics tools were assessed to predict the structure of PDGF-B and its interaction with EGFR.

Active PDGF exhibits multiple forms and ranges in size from 2835 kDa [31]. The most studied isoforms of PDGF; AA, BB and AB, have been shown to bind with different affinities to homo- and heterodimers of their receptor gene products, denoted a and B [18,32]. Depending on ligand configuration and the pattern of receptor expression, different receptor dimers may form, including homodimers and heterodimers of PDGFA-R and PDGFB-R [33]. Previous research has shown that all PDGFs have a highly conserved conserved Cystine knot-fold growth factor domain of approximately 100 amino acids (aa), called the PDGF/VEGF homology domain [34].

ClusPro: an automated docking and discrimination method for the prediction of protein complexes. Bioinformatics 20(1), 45–50 (2004) 21. : CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. J. Comput. Chem. 4, 187–217 (1983) 22. : Achieving reliability and high accuracy in automated protein docking: Cluspro, PIPER, SDU, and stability analysis in CAPRI rounds 13–19. Proteins: Structure, Function, and Bioinformatics 78, 3124–3130 (2010) Analysis of Binding Residues between PDGF-BB and Epidermal Growth Factor Receptor 39 23.

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Advances in Computational Biology: Proceedings of the 2nd Colombian Congress on Computational Biology and Bioinformatics (CCBCOL) by Ivan Mura (auth.), Luis F. Castillo, Marco Cristancho, Gustavo Isaza, Andrés Pinzón, Juan Manuel Corchado Rodríguez (eds.)


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