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By G. Hasko, et al.,

ISBN-10: 0849339995

ISBN-13: 9780849339998

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3 nM). 65 Although A3AR expression levels were low in all regions of the brain, the A3AR agonist IB-MECA 19 depressed locomotor activity in mice,69 suggesting a role for the A3AR in depression of motor activity. , 1993). 72 IB-MECA (designated CF101) 19 is in clinical trials for treatment of rheumatoid arthritis and colon carcinoma. The novel anticancer effect discovered by Fishman and colleagues is caused by a cytostatic effect on tumors related to the Wnt pathway, rather than by induction of apoptosis.

Okamura, T. , Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma, Bioorg. Med. Chem. , 14, 3775, 2004. 44. G. , Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A3 adenosine receptor antagonists: influence of the chain at the N8 pyrazole nitrogen, J. Med. , 43, 4768, 2000. 45. G. , Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A3 adenosine receptor antagonists, J.

Biagi, G. , 2,9-disubstituted-N6-(arylcarbamoyl)-8-azaadenines as new selective A3 adenosine receptor antagonists: synthesis, biochemical and molecular modeling studies, Bioorg. Med. , 13, 4679, 2005. 63. Perreira, M. , “Reversine” and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists, J. Med. , 48, 4910, 2005. 64. , A3 adenosine receptors: novel ligands and paradoxical effects, Trends Pharmacol. , 19, 184, 1998. 65. Shneyvays, V. , Activation of A3 adenosine receptor protects against doxorubicininduced cardiotoxicity, J.

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