By Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)
The target of this booklet is to supply the objective viewers, in particular scholars of drugs, Biology, structures Biology and Bioinformatics, in addition to skilled researchers in learn fields appropriate to metabolic syndrome (MetS) with an outline of the demanding situations and possibilities in platforms biology and the way it may be used to take on MetS. particularly, the goals are: (1) to supply an creation to the most important organic procedures enthusiastic about the pathophysiology of MetS; (2) by utilizing particular examples, supply an advent to the newest applied sciences that use a platforms biology method of examine MetS; and (3) to offer an summary of the mathematical modeling ways for learning MetS.
The truly written chapters through major specialists within the box presents specified descriptions the most important for the original place of this publication and its concentrate on the appliance of platforms biology to take on particular pathophysiologically proper points of MetS and offers a useful sensible consultant to this learn community.
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Additional info for A Systems Biology Approach to Study Metabolic Syndrome
2001a). LXR also regulates intestinal cholesterol absorption through the negative regulation of the intestinal sterol transporter Niemann-Pick C1-like 1 (NPC1L1) (Duval et al. 2006) and facilitates uptake and storage of cholesterol by the liver through the expression of CEPT (Luo et al. 2001). LXRs also regulate FA metabolism through the expression of SREBP-1c which is, as mentioned before, a master regulator of FA synthesis (Repa et al. 2000).
As mentioned before FAs can be both esterified to TGs or oxidized with the production of adenosine triphosphate (ATP). The uptake of FA into the mitochondria matrix is regulated by CPT-1 and -2. CPT-1 levels have been found decreased in patients with NAFLD, consequentially to the inhibition by high levels of malonyl-CoA, suggesting a reduction in mitochondrial FAO (Nakamuta et al. 2005a). However, although FAO appears to be increased in liver of both NAFLD and NASH patients (Sanyal et al. 2001), this increase is not sufficient per se to prevent TG accumulation.
J Clin Invest 116:33–35 Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219–246 Pietilainen KH, Rog T, Seppanen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepaa AL, Niemela PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyotylainen T, Rissanen A, Kaprio J, Yki-Jarvinen H, Vattulainen I, Vidal-Puig A, Oresic M (2011) Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.
A Systems Biology Approach to Study Metabolic Syndrome by Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)